oalib

OALib Journal期刊

ISSN: 2333-9721

费用：99美元

投稿

时间不限

( 2673 )

( 2672 )

( 2208 )

( 2024 )

自定义范围…

匹配条件： “ Gerald J Gleich ” ，找到相关结果约358967条。
列表显示的所有文章，均可免费获取
第1页/共358967条
每页显示 条
Cerebral Fat Embolism Syndrome from Penetrating Trauma: A Rare Cause-and-Effect  [PDF]
Stephen J. Gleich,James D. Hannon
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34052
Abstract: A 42 year-old male sustained an accidental rifle gunshot wound to his left foot, resulting in fracture deformities of the calcaneus, navicular, cuneiform, 1st and 2nd metatarsal bases, and talus. As he was transported to our trauma center, he developed progressive encephalopathy. Urgent external fixator placement under general anesthesia was postponed due to his encephalopathy of unknown etiology. Brain magnetic resonance imaging demonstrated a “starfield” pattern of infarcts, consistent with cerebral fat embolism syndrome. Subsequently, he underwent uneventful general anesthesia. The patient was managed supportively and continued to have persistent neurologic dysfunction two months after injury.
Cerebral Fat Embolism Syndrome from Penetrating Trauma: A Rare Cause-and-Effect  [PDF]
Stephen J. Gleich, James D. Hannon
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34052
Abstract:

A 42 year-old male sustained an accidental rifle gunshot wound to his left foot, resulting in fracture deformities of the calcaneus, navicular, cuneiform, 1st and 2nd metatarsal bases, and talus. As he was transported to our trauma center, he developed progressive encephalopathy. Urgent external fixator placement under general anesthesia was postponed due to his encephalopathy of unknown etiology. Brain magnetic resonance imaging demonstrated a “starfield” pattern of infarcts, consistent with cerebral fat embolism syndrome. Subsequently, he underwent uneventful general anesthesia. The patient was managed supportively and continued to have persistent neurologic dysfunction two months after injury.

Activated Eosinophils in Association with Enteric Nerves in Inflammatory Bowel Disease
Claire M. Smyth, Nadim Akasheh, Sara Woods, Elaine Kay, Ross K. Morgan, Margaret A. Thornton, Anthony O’Grady, Robert Cummins, Orla Sheils, Peter Smyth, Gerald J. Gleich, Frank M. Murray, Richard W. Costello
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064216
Abstract: Enteric neural dysfunction leads to increased mucous production and dysmotility in inflammatory bowel disease (IBD). Prior studies have shown that tissue eosinophilia is related to disease activity. We hypothesized that interactions between eosinophils and nerves contribute to neural dysfunction in IBD. Tissue from patients with intractable IBD, endoscopic biopsies from patients with steroid responsive IBD, both when active and quiescent, and control tissue were studied. Immunohistochemical studies showed that eosinophils localize to nerves in the mucosal layer of patients with Crohn’s disease (CD) (p<0.001) and ulcerative colitis (UC), (p<0.01). Eosinophils localized to substance P and choline acetyltransferase (ChAT) immunostained nerves. Real time PCR of laser capture micro-dissected enteric ganglia demonstrated Intercellular Adhesion Molecule 1 (ICAM-1) mRNA was increased 7-fold in UC (n = 4), (p = 0.03), and 10-fold in CD (n = 3), (p = 0.05). Compared with controls, eotaxin-3 (CCL-26) mRNA was increased 9-fold in UC (p = 0.04) and 15-fold in CD (p = 0.06). Eosinophil numbers correlated with disease activity, while deposition of major basic protein (MBP) and eosinophil Transforming Growth Factor β -1 (TGFβ-1) expression were seen in therapeutically responsive disease. These data indicate a significant localization of eosinophils to nerves in IBD, mediated through neurally expressed ICAM-1 and eotaxin-3. This cell/neural interaction may influence the function of nerves and contribute to symptoms in IBD.
Remote magnetic actuation using a clinical scale system
Bernhard Gleich,Christian Stehning,Jürgen Rahmer
- , 2018, DOI: 10.1371/journal.pone.0193546
Abstract:
ICON: eosinophil disorders
Peter Valent, Amy D Klion, Lanny J Rosenwasser, Michel Arock, Bruce S Bochner, Joseph H Butterfield, Jason Gotlib, Torsten Haferlach, Andrzej Hellmann, Hans-Peter Horny, Kristin M Leiferman, Georgia Metzgeroth, Kenji Matsumoto, Andreas Reiter, Florence Roufosse, Marc E Rothenberg, Hans-Uwe Simon, Karl Sotlar, Peter Vandenberghe, Peter F Weller, Gerald J Gleich
World Allergy Organization Journal , 2012, DOI: 10.1097/wox.0b013e31827f4192
Abstract:
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
Amy D. Klion,Andrew F. Walls,Anne-Marie Irani,Calman Prussin,Cem Akin,Dean D. Metcalfe,Francesca Levi-Schaffer,Franco H. Falcone,Frederic Clayton,Gerald J. Gleich,Gunnar Nilsson,Hans-Uwe Simon,John T. Schroeder,Kristin M. Leiferman,Lawrence B. Schwartz,Massimo Triggiani,Mats W. Johansson,Ruby Pawankar,Steven J. Ackerman,Yoshimichi Okayama
- , 2016, DOI: 10.1186/s40413-016-0094-3
Abstract: Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology
Measuring Criticality of Raw Materials: An Empirical Approach Assessing the Supply Risk Dimension of Commodity Criticality  [PDF]
Herbert Mayer, Benedikt Gleich
Natural Resources (NR) , 2015, DOI: 10.4236/nr.2015.61007
Abstract: Providing a sustainable and reliable supply of raw materials at economic prices has become essential to industrialized economies. Therefore, the need for both economical and sustainable methods and strategies for the management of raw materials has been postulated to enable companies and economies to counteract dramatic effects of supply disruptions, or at least to provide early warnings. The relevant studies assign generic weights to different driving factors and therefrom derive criticality indexes. However, it often remains open how to interpret the resulting measures and how to apply them practically. Here we show that based on current commodity key figures, it is possible to empirically determine the risk for future price increases and fluctuations. Thus, we can identify future supply risks and incorporate their patterns into an empirically calibrated criticality measurement. To this end, we apply the well-known compounding framework used by many companies for their financial planning, calculating net present values and volatility from the predicted future price development. To calibrate each resource specific model, we perform extended regression analyses on our compounded criticality index from time series of 42 (out of about 60 industrially relevant) chemical elements. The analysis thereby covers 9 driving factors for criticality and a 40-year time span. Our results suggest a fundamental modification of current practices for criticality assessment, in particular by scaling the criticality measure to correspond with the net present value of future commodity expenses and future volatility.
Measuring Criticality of Raw Materials: An Empirical Approach Assessing the Supply Risk Dimension of Commodity Criticality  [PDF]
Herbert Mayer, Benedikt Gleich
Natural Resources (NR) , 2015, DOI: 10.4236/nr.2015.61007
Abstract: Providing a sustainable and reliable supply of raw materials at economic prices has become essential to industrialized economies. Therefore, the need for both economical and sustainable methods and strategies for the management of raw materials has been postulated to enable companies and economies to counteract dramatic effects of supply disruptions, or at least to provide early warnings. The relevant studies assign generic weights to different driving factors and therefrom derive criticality indexes. However, it often remains open how to interpret the resulting measures and how to apply them practically. Here we show that based on current commodity key figures, it is possible to empirically determine the risk for future price increases and fluctuations. Thus, we can identify future supply risks and incorporate their patterns into an empirically calibrated criticality measurement. To this end, we apply the well-known compounding framework used by many companies for their financial planning, calculating net present values and volatility from the predicted future price development. To calibrate each resource specific model, we perform extended regression analyses on our compounded criticality index from time series of 42 (out of about 60 industrially relevant) chemical elements. The analysis thereby covers 9 driving factors for criticality and a 40-year time span. Our results suggest a fundamental modification of current practices for criticality assessment, in particular by scaling the criticality measure to correspond with the net present value of future commodity expenses and future volatility.
Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells
Richard W. Costello,Michael Maloney,Mazin Atiyeh,Gerald Gleich,Marie-Therese Walsh
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12053237
Abstract: The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P 1–5 and LPA 1–3 respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The G i coupled receptors S1P 1, S1P 3, LPA 1, LPA 2 and LPA 3 were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and G i-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and G i-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P 1, LPA 1, LPA 2 and LPA 3, providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.
Theory, simulation and experimental results of the acoustic detection of magnetization changes in superparamagnetic iron oxide
Bernhard Gleich, Jürgen Weizenecker, J？rn Borgert
BMC Medical Imaging , 2011, DOI: 10.1186/1471-2342-11-16
Abstract: Starting from an introduction to the theory of acoustically detected Magnetic Particle Imaging, a comparison to magnetically detected Magnetic Particle Imaging is presented. Furthermore, an experimental setup for the detection of acoustic emissions is described, which consists of the necessary field generating components, i.e. coils and permanent magnets, as well as a calibrated microphone to perform the detection.The estimated detection limit of acoustic Magnetic Particle Imaging is comparable to the detection limit of magnetic resonance imaging for iron oxide nanoparticles, whereas both are inferior to the theoretical detection limit for magnetically detected Magnetic Particle Imaging. Sufficient data was acquired to perform a comparison to the simulated data. The experimental results are in agreement with the simulations. The remaining differences can be well explained.It was possible to demonstrate the detection of acoustic emissions of magnetic tracer materials in Magnetic Particle Imaging. The processing of acoustic emission in addition to the tracer distribution acquired by magnetic detection might allow for the extraction of mechanical tissue parameters. Such parameters, like for example the velocity of sound and the attenuation caused by the tissue, might also be used to support and improve ultrasound imaging. However, the method can also be used to perform imaging on its own.Magnetic Particle imaging (MPI) is a novel method for medical imaging. It can be used to measure the local concentration of a tracer material based on iron oxide nanoparticles. While the resulting images show the distribution of the tracer material in phantoms or anatomic structures of subjects under examination, no information about the circumjacent tissue is being acquired. To expand MPI into the detection of soft tissue properties, a new method is proposed, which detects acoustic emissions caused by magnetization changes in superparamagnetic iron oxide. These signals may allow for t
第1页/共358967条
每页显示 条


Home
Copyright © 2008-2020 Open Access Library. All rights reserved.